We study the effects of different labor market policies on employment composition in a matching model with salaried work and self-employment. We empirically assess some of the model’s predictions using micro data from the European Union Household Panel. Policies such as employment protection legislation and compulsory social security contributions of the self-employed, and their interactions, are relevant to explain the composition of employment in the European labor market. One major policy implication of this result is the need for a convenient policy mix definition.